Phosphonoacetic Acid in the Treatment of Experimental Herpes Simplex Keratitis

Phosphonoacetic acid in the treatment of experimental herpes simplex keratitis.

In a rabbit model of herpes simplex corneal ulceration, 5% phosphonoacetic acid solution or ophthalmic ointment suppressed clinical disease and virus replication. The effect of 5% phosphonoacetic acid ointment was equivalent to that of 0.5% idoxuridine ointment in the treatment of this established herpetic eye infection.

Effect of phosphonoacetic acid in the treatment of experimental herpes simplex keratitis.

In the rabbit 5% phosphonoacetic acid ointment suppressed herpetic keratitis as well as 0-5% idoxuridine ointment. After 5 days of treatment quantitative virus titres showed that phosphonoacetic acid was superior to idoxuridine in the inhibition of herpes virus replication. Phosphonoacetic acid was found to be nontoxic to the eye in both clinical and histopathological studies. Recent reports su...

Phosphonoacetic acid in the treatment of experimental ocular herpes simplex infections.

Phosphonoacetic acid had a significant antiviral effect when applied topically, both in liquid and ointment preparations, on superficial herpetic keratitis in rabbits and was equally as effective as idoxuridine. It was also effective in the treatment of idoxuridine-resistant herpetic keratitis. Phosphonoacetic acid was not effective in the treatment of experimental herpetic iritis when applied ...

Photodynamic inactivation in the treatment of experimental herpes simplex keratitis.

Gamma Globulin in Experimental Herpes Simplex Keratitis.

The chronic keratitis resulting from the steroid treatment of acute herpes simplex infection of the rabbit cornea was significantly improved by the subconfunctival administration of either human or rabbit gamma globulin, the latter possessing no neutralizing antibody to herpes simplex virus. Virus titrations of this late lesion were consistently negative. The etiological and therapeutic implica...